Purpose

Recent developments emphasize the ready conversion of known active pharmaceutical ingredients (APIs) into novel phases like ionic liquids (known green solvents) to obtain striking features such as improved solubilities and dissolution rates. This dissolution enhancement is important for the pharmacodynamics and pharmacokinetics of the drug. For this purpose, an active cation can be combined with an active anion to synthesize dual functionality liquid.

Methods

In this work, we synthesized two novel ionic liquids, cholinium arbutinate (IL-1) and cholinium glutathionate (IL-2), from cosmetic grade components and evaluated their prospective applications as skin whitening. For this purpose, two known whitening acids, arbutin and glutathione, were neutralized with choline hydroxide. Synthesized ionic liquids were characterized via NMR and FTIR as well as evaluated for their potent biological properties involving antibacterial, antifungal, cytotoxicity, and de-pigmenting activity.

Results

The results suggested that synthesized ionic liquids can be used as skin whitening agents as they can prevent bacterial attack, protect from cell oxidation, and also exhibit cell compatibility. Furthermore, these novel synthesized compounds were observed to have de-pigmenting activity.

Conclusion

The prepared whitening agents would not cause any harm to the skin and would inhibit the growth of bacteria and oxidation of cells, thus preventing cell damage.

中文翻译：

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化妆品级离子液体的合成、表征及其作为皮肤美白剂的应用

目的

最近的发展强调可以将已知的活性药物成分 (API) 随时转化为离子液体（已知的绿色溶剂）等新型相，以获得显着的特征，例如改善的溶解度和溶出速率。这种溶出增强对于药物的药效学和药代动力学非常重要。为此，可以将活性阳离子与活性阴离子结合以合成双功能液体。

方法

在这项工作中，我们从化妆品级成分合成了两种新型离子液体：熊果酸胆碱酯 (IL-1) 和谷胱甘肽胆碱酯 (IL-2)，并评估了它们作为皮肤美白的潜在应用。为此，用氢氧化胆碱中和两种已知的美白酸：熊果苷和谷胱甘肽。通过 NMR 和 FTIR 对合成的离子液体进行了表征，并评估了其有效的生物特性，包括抗菌、抗真菌、细胞毒性和脱色活性。

结果

结果表明，合成的离子液体可以用作皮肤美白剂，因为它们可以防止细菌侵袭，防止细胞氧化，并且还表现出细胞相容性。此外，观察到这些新合成的化合物具有脱色活性。

结论

所制备的美白剂不会对皮肤造成任何伤害，并且能抑制细菌的生长和细胞的氧化，从而防止细胞损伤。