An analytical method for quantifying the volatile anticancer drugs ifosfamide (IF) and cyclophosphamide (CP) in air was developed on the basis of thermal desorption (TD)-gas chromatography-mass spectrometry. Polydimethylsiloxane-coated macroporous silica was used as the adsorbent. The extraction tube was prepared by packing 0.2 g of adsorbent particles into a glass tube. The extraction and desorption efficiencies of the proposed method were quantitatively investigated in this study. The limits of detection of the proposed method for IF and CP were 3.3 ng L-1 at an air sampling volume of 3.0 L (30 min). The sensitivity of the proposed method was compared with using a Tenax TA packed tube that is widely used as the extraction medium in TD analysis. Finally, detection of IF and CP that evaporated from aqueous standard solution was investigated.

中文翻译：

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气相色谱-质谱联用聚二甲基硅氧烷涂层大孔二氧化硅吸附剂热解吸技术测定挥发性抗癌药物。

建立了基于热解吸（TD）-气相色谱-质谱联用技术定量空气中挥发性抗癌药物异环磷酰胺（IF）和环磷酰胺（CP）的分析方法。使用聚二甲基硅氧烷涂覆的大孔二氧化硅作为吸附剂。通过将0.2g吸附剂颗粒填充到玻璃管中来制备提取管。本研究对所提出方法的萃取和解吸效率进行了定量研究。在空气采样体积为 3.0 L（30 分钟）时，所提出的 IF 和 CP 方法的检测限为 3.3 ng L-1。将所提出方法的灵敏度与使用 Tenax TA 填充管进行比较，后者在 TD 分析中广泛用作提取介质。最后，研究了从标准水溶液中蒸发的 IF 和 CP 的检测。