:: The review highlights recent advancements in the synthesis of α-fluoro and α,α- difluoroalkylated azines, focusing on two main approaches. The first approach involves nucleophilic deoxofluorination, wherein α-hydroxy- or α-oxoalkylated azines are treated with diethylaminosulfur trifluoride or other S-F reagents to introduce fluorine atoms. The second approach employs direct electrophilic benzylic fluorination, whereby alkylazines undergo fluorination using N-F reagents. Both methods provide flexibility in designing and synthesizing fluoroalkylated heterocycles.

中文翻译：

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直接氟化合成α-氟烷基化吖嗪衍生杂环的最新进展

* 审查强调了α-氟和α,α-二氟烷基化吖嗪合成方面的最新进展，重点关注两种主要方法。第一种方法涉及亲核脱氧氟化，其中用二乙氨基三氟化硫或其他SF试剂处理α-羟基-或α-氧代烷基化吖嗪以引入氟原子。第二种方法采用直接亲电苄基氟化，其中烷基嗪使用 NF 试剂进行氟化。这两种方法都为设计和合成氟烷基化杂环提供了灵活性。