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Incidence and risk factors of venous thromboembolism in kidney transplantation patients: a prospective cohort study
Journal of Thrombosis and Thrombolysis ( IF 4 ) Pub Date : 2023-11-28 , DOI: 10.1007/s11239-023-02911-w
Shangping Zhao 1 , Hong Chen 2 , Xiaoying Shi 1 , Qiling Tan 1 , Bo Gu 1
Affiliation  

To investigate the incidence and explore the risk factors of venous thromboembolism (VTE) within 6 months after kidney transplantation. Total of 331 kidney transplant recipients were assessed by venous ultrasonography for VTE at 14 days, 1 month, 3 months, and 6 months post-transplantation. Cox forward regression were used to identify the independent risk factors of VTE. This study registration number is ChiCTR1900020567 and the date of registration was 2019/01/08. The cumulative incidence of VTE was 2.72% (9/331) within 6 months after transplant. 77.8% (7/9) of VTEs occurred in the first 3 months post-transplantation. 88.9% (1/9) of VTEs were asymptomatic, 66.7% (6/9) of VTEs were mural thromboses and in the right lower extremity. Central vena catheterization (HR = 6.94) and severe pulmonary disease (including pneumonia) (HR = 57.35) were the risk factors for VTE in kidney transplantation recipients. KT patients are the high risk population of VTE. Future interventions should be strengthen for KT patients to receive a minimum of 3-month of precautionary measures for VTE, including infection prevention, and strengthening thromboprophylaxis on the CVC or transplanted side of lower extremity.



中文翻译:

肾移植患者静脉血栓栓塞的发生率和危险因素:一项前瞻性队列研究

调查肾移植术后6个月内静脉血栓栓塞(VTE)的发生情况并探讨其危险因素。共有 331 名肾移植受者在移植后 14 天、1 个月、3 个月和 6 个月时通过静脉超声检查评估 VTE。Cox正向回归用于识别VTE的独立危险因素。本研究注册号为ChiCTR1900020567,注册日期为2019/01/08。移植后6个月内VTE累积发生率为2.72%(9/331)。77.8% (7/9) 的 VTE 发生在移植后的前 3 个月。88.9% (1/9) 的 VTE 无症状,66.7% (6/9) 的 VTE 为附壁血栓且发生在右下肢。中心静脉导管插入术(HR=6.94)和严重肺部疾病(包括肺炎)(HR=57.35)是肾移植受者发生VTE的危险因素。KT患者是VTE的高危人群。未来应加强对KT患者的干预,接受至少3个月的VTE预防措施,包括预防感染、加强CVC或下肢移植侧的血栓预防。

更新日期:2023-11-28
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