In all cells—from bacteria to humans—nucleotide excision repair (NER) is a highly conserved, versatile DNA repair pathway that is responsible for the removal of a wide variety of DNA helix-distorting lesions arising from both endogenous and exogenous sources. In many organisms including bacteria, fungi, animals, and plants, NER occurs through two sub-pathways: the global genome NER (GG-NER) pathway and the transcription-coupled NER (TC-NER) pathway. Although essential factors and basic steps involved in NER have been identified, mechanisms and stages of their assembly process are not well understood. In this review, we summarize recent literature about protein interaction networks that manifest during initial stages of bacterial NER pathway while highlighting some of the key functional studies.

在从细菌到人类的所有细胞中，核苷酸切除修复 (NER) 是一种高度保守、多功能的 DNA 修复途径，负责去除内源性和外源性来源的各种 DNA 螺旋扭曲损伤。在包括细菌、真菌、动物和植物在内的许多生物体中，NER 通过两个子途径发生：全局基因组 NER (GG-NER) 途径和转录偶联 NER (TC-NER) 途径。尽管NER所涉及的基本因素和基本步骤已经被确定，但其组装过程的机制和阶段尚不清楚。在这篇综述中，我们总结了有关细菌 NER 通路初始阶段出现的蛋白质相互作用网络的最新文献，同时重点介绍了一些关键的功能研究。