Purpose

Elderly patients with type 2 diabetes mellitus (T2DM) may have a higher risk of physical disability. This study investigated the incidence of gastric cancer according to physical disability status in elderly patients with T2DM.

Methods

The National Health Insurance Service claims data were used. A total of 76,162 participants aged 60 years or above, diagnosed with T2DM, were included. The association between physical disability status and gastric cancer incidence was evaluated using the Cox regression analysis. Additionally, subgroup analysis was performed according to region.

Results

A total of 9,154 (12.0%) individuals had physical disability. Gastric cancer incidence was more common in participants with physical disability (3.3%) than those without (2.4%). A higher risk of gastric cancer incidence was found in elderly T2DM patients with physical disability (Hazard Ratio (HR) 1.18, 95% Confidence Interval (95% CI) 1.04–1.34). Such tendencies were maintained regardless of region, although the effect of physical disability status on gastric cancer incidence was particularly significant in individuals residing in non-metropolitan areas (HR: 1.19, 95% CI: 1.01–1.40).

Conclusion

Elderly patients with T2DM who had physical disability showed a higher risk of gastric cancer incidence. The findings suggest a need to monitor elderly T2DM patients with disability as they may be susceptible to difficulties in accessing cancer-related healthcare.

中文翻译：

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身体残疾对老年糖尿病患者胃癌发病风险的影响：关注地区差异

目的

患有 2 型糖尿病 (T2DM) 的老年患者可能有更高的身体残疾风险。本研究根据老年 T2DM 患者的身体残疾状况调查了胃癌的发病率。

方法

使用了国民健康保险公团的索赔数据。共有 76,162 名 60 岁或以上被诊断患有 T2DM 的参与者纳入研究。使用 Cox 回归分析评估身体残疾状况与胃癌发病率之间的关联。此外，还根据地区进行了亚组分析。

结果

共有 9,154 人（12.0%）有身体残疾。患有身体残疾的参与者 (3.3%) 比没有身体残疾的参与者 (2.4%) 更容易患胃癌。身体残疾的老年 T2DM 患者患胃癌的风险较高（风险比 (HR) 1.18，95% 置信区间 (95% CI) 1.04–1.34）。尽管身体残疾状况对居住在非大都市地区的个体胃癌发病率的影响尤其显着（HR：1.19，95％CI：1.01-1.40），但无论在哪个地区，这种趋势都维持着。

结论

有身体残疾的老年 T2DM 患者患胃癌的风险较高。研究结果表明，需要监测患有残疾的老年 T2DM 患者，因为他们可能容易在获得癌症相关医疗保健方面遇到困难。