Background: Bimetallic catalysis plays a major role in boosting the catalytic performance of monometallic counterparts due to the synergetic effect. Materials and Methods: In the present study, we have exploited ZrCl4:Mg(ClO4)2 as an efficient bimetallic catalyst for the synthesis of a few biologically relevant N-substituted decahydroacri-dine-1,8-diones and xanthene-1,8-diones under solvent-free conditions. The complete characterization data (XRD, SEM, BET, pH, TGA, and IR) of the bimetallic catalyst, ZrCl4: Mg(ClO4)2, are provided in the supporting information. Results: Among the compounds screened for anti-oxidant and anti-microbial activities, the ac-ridine derivatives with chloro and fluoro substitutions (compounds 4b, 4c, 4d, and 4j) have ex-hibited potent activities when compared to other compounds. Among the xanthene derivatives screened for anti-oxidant activity, compounds 5c, 5i, and 5j with chloro and nitro derivatives exhibited potent antioxidant activity, and the rest all showed moderately potent activity. Conclusion: Among the compounds screened for antibacterial activity, compound 5j with chloro substitution showed potent activity, followed by compounds 5c, 5d, 5h, and 5i against Gram +ve bacteria, and compounds 5h, 5f, and 5g with N,N-dimethyl, methoxy and hydroxy substitutions have shown potent activity against Gram -ve bacteria.

中文翻译：

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用于合成 N-取代十氢吖啶-1,8-二酮和呫吨-1,8-二酮的高效双金属催化剂：其生物活性评价

背景：由于协同效应，双金属催化在提高单金属对应物的催化性能方面发挥着重要作用。材料和方法：在本研究中，我们利用 ZrCl4:Mg(ClO4)2 作为有效的双金属催化剂来合成一些生物学相关的 N-取代十氢吖啶-1,8-二酮和呫吨-1,8 -无溶剂条件下的二酮。支持信息中提供了双金属催化剂 ZrCl4: Mg(ClO4)2 的完整表征数据（XRD、SEM、BET、pH、TGA 和 IR）。结果：在筛选的抗氧化和抗微生物活性的化合物中，与其他化合物相比，具有氯和氟取代的吖啶衍生物（化合物4b、4c、4d和4j）具有有效的活性。在筛选的抗氧化活性的呫吨衍生物中，具有氯代和硝基衍生物的化合物5c、5i和5j表现出较强的抗氧化活性，其余的均表现出中等强度的活性。结论：筛选的化合物中，氯取代的化合物5j显示出较强的抗菌活性，其次是化合物5c、5d、5h和5i对革兰氏+ve细菌，以及带有N,N-二甲基的化合物5h、5f和5g。 、甲氧基和羟基取代已显示出针对革兰氏阴性细菌的有效活性。