Abstract

Cefpodoxime proxetil (CP) solubility in binary solvent mixtures (1,4-dioxane + water and acetonitrile + water) was tested using the gravimetric method at temperature between 298.15 to 318.15 K and under normal atmospheric pressure. The experimental mole fraction solubility of CP was increased with increasing temperature as well as with the proportion of co-solvent in all systems. Then Apelblat, Buchowski-Ksiazczak, Van’t Hoff, \(CNIBS{\text{/}}R{-} K\) and the modified Jouyban-Acree models were used for the prediction of the theoretical mole fraction solubility of CP. The experimental and theoretical mole fraction solubility were found to be good in this arrangement. Additionally, thermodynamics modeling of CP was carried out by using Van’t Hoff’s equation. The data on the solubility and thermodynamics would be useful in the production, isolation, separation, and crystallization of CP.