This study investigates the relationship between long COVID and health-related quality of life (HRQOL) in patients discharged for 6 months. It included 192 patients with a history of severe COVID-19 and 192 patients with a history of non-severe COVID-19 patients that were selected through quota sampling methods from the Medical Care Monitoring Center (MCMC) of hospitals in Shiraz, Iran, in 2020. Phone-based interviews were conducted to collect data using the short form of the 12-item health-related quality of life (SF-12) questionnaire. Descriptive statistics, including mean (standard deviation) and frequency (percentage), were utilized. Statistical tests, such as the chi-squared test, independent samples t-test, Fisher’s exact test, and multiple linear regression models were performed. Statistical analysis was performed using SPSS software version 24, with a significance level of 0.05. Among 384 patients, 79.95% were married, with a mean age of 53.95 years. The majority of patients in both groups were male (57.81% in the severe group and 51.04% in the non-severe group). Patients with severe COVID-19 had significantly lower quality of life scores compared to those with non-severe COVID-19 (p < 0.001, 34.45 [SD = 6.59] versus 39.64 [SD = 5.07]). Furthermore, multiple linear regression analysis indicated that severe COVID-19 inducts a significant negative effect on HRQOL in patients after adjustment of confounders (p < 0.001, B = − 4.84). Patients with severe COVID-19 had lower HRQOL compared to those with a non-severe level. It is necessary to consider implementing policies aimed at providing social, psychological, or medical support to improve the HRQOL of patients with a history of severe COVID-19.

本研究调查了出院 6 个月患者的长期新冠肺炎与健康相关生活质量 (HRQOL) 之间的关系。其中包括 192 名有重症 COVID-19 病史的患者和 192 名有非重症 COVID-19 病史的患者，这些患者是通过配额抽样方法从伊朗设拉子医院医疗监测中心 (MCMC) 中挑选出来的。 2020 年。使用包含 12 项健康相关生活质量 (SF-12) 问卷的简短形式进行电话访谈来收集数据。使用了描述性统计数据，包括平均值（标准差）和频率（百分比）。进行了统计检验，例如卡方检验、独立样本t检验、Fisher精确检验和多元线性回归模型。采用SPSS软件24版进行统计分析，显着性水平为0.05。384名患者中，79.95%已婚，平均年龄53.95岁。两组患者均以男性为主（重症组57.81%，非重症组51.04%）。与非重症 COVID-19 患者相比，重症 COVID-19 患者的生活质量评分显着较低（p  < 0.001, 34.45 [SD = 6.59] vs 39.64 [SD = 5.07]）。此外，多元线性回归分析表明，在调整混杂因素后，严重的 COVID-19 对患者的 HRQOL 产生显着的负面影响（p  < 0.001，B  = − 4.84）。与非重症患者相比，重症 COVID-19 患者的 HRQOL 较低。有必要考虑实施旨在提供社会、心理或医疗支持的政策，以改善有重症 COVID-19 病史的患者的 HRQOL。