Protein arginine methylation stands as a prevalent post-translational modification process, exerting vital roles in cellular signal transduction, gene expression, and cell cycle regulation. Amidst the protein arginine methyltransferase (PRMT) family, PRMT2 stands as a less explored constituent. Nonetheless, its regulatory roles in transcriptional regulation, post-transcriptional modification, methylation activity regulation, immunoregulation, and developmental regulation have garnered attention. These capabilities enable PRMT2 to exert pivotal regulatory functions in certain malignancies, metabolic disorders, inflammatory diseases, and atherosclerosis. In this review, we highlight the structure and functions of PRMT2, emphasizing its association with diseases. We also discuss PRMT2 inhibitors and explore the potential for therapeutic targeting.

中文翻译：

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蛋白质精氨酸甲基转移酶2的功能与疾病研究进展

蛋白质精氨酸甲基化是一种普遍存在的翻译后修饰过程，在细胞信号转导、基因表达和细胞周期调节中发挥着重要作用。在蛋白质精氨酸甲基转移酶 (PRMT) 家族中，PRMT2 是一个较少被研究的成分。尽管如此，其在转录调节、转录后修饰、甲基化活性调节、免疫调节和发育调节等方面的调节作用引起了人们的关注。这些功能使 PRMT2 能够在某些恶性肿瘤、代谢紊乱、炎症性疾病和动脉粥样硬化中发挥关键的调节功能。在这篇综述中，我们重点介绍了 PRMT2 的结构和功能，强调其与疾病的关联。我们还讨论了 PRMT2 抑制剂并探索治疗靶向的潜力。