Liposomes have emerged as pivotal entities in the field of therapeutics, particularly in the domain of protein and vaccine administration. Hence, the development of novel liposomal formulations has garnered considerable interest. Liposomal delivery systems are considered advantageous as medication carriers, especially in the field of dermatology, owing to their moisturizing and restorative characteristics. Nevertheless, a significant drawback in the utilization of liposomes in topical applications is the inherent fluidity of the formulation, which might result in leakage following delivery to the skin surface. The use of liposomes inside the gel matrix, while maintaining the integrity of the vesicles, presents a potentially appealing method for topical administration. The primary objective of this work is to develop a liposomal-loaded gel formulation and assess its in vitro release characteristics as well as its rheological profile, including viscoelastic properties and flow behaviour. This study incorporated two different types of drugs, namely hydrophilic (specifically diphenhydramine hydrochloride) and hydrophobic (namely curcumin), inside its formulations. A liposome, composed of a long alkyl chain lipid such as DPPC with a chain length of 16, was synthesized using the thin film hydration process and subsequently integrated into a carbopol gel. It is noteworthy that the introduction of diphenhydramine hydrochloride (DPH) resulted in a substantial decrease in the elastic modulus and cohesiveness of the liposomal gel. Conversely, the incorporation of curcumin-loaded liposomal gel led to an increase in critical strain and cohesiveness when compared to the plain liposomal gel. In contrast, the liposomal gel containing DPH and curcumin demonstrated a reduced release rate compared to the plain liposomal gel, spanning a duration of 48 h. The in vitro release studies offer the potential for the utilization of liposomal gels as a sustained delivery system.

脂质体已成为治疗领域的关键实体，特别是在蛋白质和疫苗施用领域。因此，新型脂质体制剂的开发引起了人们的极大兴趣。脂质体递送系统由于其保湿和恢复特性而被认为作为药物载体是有利的，特别是在皮肤病学领域。然而，在局部应用中使用脂质体的一个显着缺点是制剂固有的流动性，这可能导致递送到皮肤表面后的泄漏。在凝胶基质内使用脂质体，同时保持囊泡的完整性，为局部给药提供了一种潜在的有吸引力的方法。这项工作的主要目标是开发一种脂质体凝胶制剂，并评估其体外释放特性及其流变特性，包括粘弹性和流动行为。这项研究在其配方中加入了两种不同类型的药物，即亲水性（特别是盐酸苯海拉明）和疏水性（即姜黄素）。采用薄膜水合工艺合成了由长烷基链脂质（例如链长为 16 的 DPPC）组成的脂质体，然后整合到卡波姆凝胶中。值得注意的是，盐酸苯海拉明（DPH）的引入导致脂质体凝胶的弹性模量和内聚性大幅下降。相反，与普通脂质体凝胶相比，加入姜黄素负载的脂质体凝胶导致临界应变和内聚性增加。相比之下，与普通脂质体凝胶相比，含有 DPH 和姜黄素的脂质体凝胶的释放速率降低，持续时间为 48 小时。体外释放研究提供了利用脂质体凝胶作为持续递送系统的潜力。