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Recent Advances in the Construction of Coumarin or Quinolin-2-ones Compounds via Radical Cascade Reactions
Mini-Reviews in Organic Chemistry ( IF 2.3 ) Pub Date : 2024-01-05 , DOI: 10.2174/0118756298278048231205053801
Shuo Zhang 1 , Wei Tang 1 , Kai Zhou 1 , Xiao-Xiao Huan 1 , Zhi-Wei Chen 1
Affiliation  

: Free radical reactions occupy an important position in synthetic organic chemistry as well as medicinal chemistry, significantly complementing and extending the synthesis of coumarin or quinolin-2-one compounds. Moreover, the use of constructing coumarin or quinolin-2-one compounds functionalized at the C3 position has certain advantages over traditional noble metalcatalyzed or high-temperature cyclization, which is more in line with the advocates of green chemistry. The design of alkenes or alkynes as radical acceptors for cascade reactions presents a novel and robust approach to obtaining coumarin or quinolin-2-one molecules. These radical cascade cyclization reactions have been well explored and studied over the past decade. As a result, we have compiled a review of the rapidly developing cutting-edge research in this field, featuring typical examples and in-depth exploration of the underlying mechanisms.

中文翻译:

通过自由基级联反应构建香豆素或喹啉-2-酮化合物的最新进展

:自由基反应在合成有机化学以及药物化学中占有重要地位,显着补充和扩展了香豆素或喹啉-2-酮化合物的合成。而且,利用构建C3位官能化的香豆素或喹啉-2-酮化合物,较传统的贵金属催化或高温环化具有一定的优势,更符合绿色化学的倡导。烯烃或炔烃作为级联反应自由基受体的设计提供了一种新颖且可靠的方法来获得香豆素或喹啉-2-酮分子。在过去的十年中,这些自由基级联环化反应已经得到了很好的探索和研究。为此,我们对这一领域快速发展的前沿研究进行了综述,以典型案例和深入探讨其背后的机制为特色。
更新日期:2024-01-05
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