Purpose

This study aimed to prepare and characterize a topical niosomal formulation of benzoyl peroxide (BP) and clindamycin phosphate (CMP) for the treatment of acne vulgaris.

Methods

Different combinations of Polyoxyethylene Alkyl Ethers (Brij), sorbitan esters (Span), and their ethoxylated derivatives (Tween), and cholesterol were used to produce the niosomes. Encapsulation, release, chemical and physical stabilities of the prepared formulations were studied.

Results

The studied niosomes exhibited high physical stability, as evidenced by unchanged size distribution over a six-month storage period. Formulations composed of Brij-52 combined with 50 mol% of cholesterol showed the highest encapsulation efficiency for both CMP (81.5 ± 7.4%) and BP (95.6 ± 3.5%). The release rate of CMP was found to be greater than BP.

Conclusions

It was concluded that niosomes could serve as stable carriers for topical drug delivery of CMP and BP, specifically in the treatment of acne vulgaris.

中文翻译：

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过氧化苯甲酰克林霉素磷酸酯类脂质体治疗寻常痤疮的制备及理化性质

目的

本研究旨在制备并表征用于治疗寻常痤疮的过氧化苯甲酰 (BP) 和磷酸克林霉素 (CMP) 的局部脂质体制剂。

方法

使用聚氧乙烯烷基醚（Brij）、脱水山梨糖醇酯（Span）及其乙氧基化衍生物（Tween）和胆固醇的不同组合来生产类脂质体。研究了所制备制剂的封装、释放、化学和物理稳定性。

结果

所研究的囊泡表现出较高的物理稳定性，六个月储存期内尺寸分布未发生变化就证明了这一点。由 Brij-52 与 50 mol% 胆固醇组合而成的制剂对 CMP (81.5 ± 7.4%) 和 BP (95.6 ± 3.5%) 表现出最高的包封率。发现 CMP 的释放速率大于 BP。

结论

结论是，纳米体可以作为 CMP 和 BP 局部药物递送的稳定载体，特别是在寻常痤疮的治疗中。