Impulse control disorders (ICDs) are a group of non-motor symptoms of Parkinson disease (PD) leading to significant psychosocial detrimental outcome. The mesocorticolimbic network plays a distinctive role in reward learning and executive decision making and has been suggested to be involved in ICDs in PD. To study morphometric changes of the mesocorticolimbic network in PD with ICD. A total of 18 patients of PD with ICD (PD + ICD), 19 patients of PD without ICD (PD − ICD) and 19 healthy controls (HC) were included in the study. ICDs were diagnosed using Questionnaire for Impulsive-Compulsive Disorders in PD-Rating Scale (QUIP-RS). MRI was done using a 3T scanner and assessment of cortical thickness and subcortical volumes were done using FreeSurfer. Brain regions known to be part of the mesocorticolimbic network were extracted and included for statistical analysis. There was no difference between PD + ICD and PD − ICD with regard to duration of illness or total dopaminergic medication. In comparison to HC, patients with PD + ICD demonstrated atrophy of the left frontal pole, and this atrophy neared significance in comparison to PD − ICD. The QUIP-RS had a negative correlation with left caudate volume in PD + ICD. The PD + ICD group showed distinct morphometric changes in regions involved in the mesocorticolimbic system which may contribute to the presence of ICD.

冲动控制障碍 (ICD) 是帕金森病 (PD) 的一组非运动症状，可导致严重的心理社会不良后果。中皮质边缘网络在奖励学习和执行决策中发挥着独特的作用，并被认为参与 PD 的 ICD。研究 ICD 患者 PD 中皮质边缘网络的形态变化。该研究共纳入 18 名患有 ICD 的 PD 患者（PD + ICD）、19 名不带 ICD 的 PD 患者（PD – ICD）和 19 名健康对照者（HC）。ICD 的诊断使用 PD 评级量表中的冲动强迫症问卷 (QUIP-RS)。使用 3T 扫描仪进行 MRI，并使用 FreeSurfer 评估皮质厚度和皮质下体积。提取已知属于中皮质边缘网络一部分的大脑区域并进行统计分析。PD + ICD 和 PD – ICD 在病程或总多巴胺能药物治疗方面没有差异。与HC相比，PD+ICD患者表现出左额极萎缩，并且与PD-ICD相比，这种萎缩接近显着性。PD + ICD 中 QUIP-RS 与左尾状核体积呈负相关。PD + ICD 组中皮质边缘系统相关区域显示出明显的形态变化，这可能导致 ICD 的存在。