Microbiome diversity has been associated with improved outcomes after allogeneic stem-cell transplantation in patients with hematological cancers. Multimodal analysis of intestinal microbiome and metabolome data helped identify immunomodulatory microbial metabolites that were predictive of survival, transplant-related mortality and cancer relapse. These metabolites were products of short-chain-fatty-acid-synthesis pathways, and their associated genes were expressed by both bacterial species and bacteriophages.

中文翻译：

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免疫调节微生物代谢物作为干细胞移植结果的潜在预测因子

微生物组多样性与血液癌症患者异体干细胞移植后预后的改善有关。肠道微生物组和代谢组数据的多模式分析有助于识别可预测生存、移植相关死亡率和癌症复发的免疫调节微生物代谢物。这些代谢物是短链脂肪酸合成途径的产物，其相关基因由细菌物种和噬菌体表达。