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Enhanced antifungal properties of the Ag-decorated GO and rGO nanocomposites for medical applications
Bulletin of Materials Science ( IF 1.8 ) Pub Date : 2024-01-25 , DOI: 10.1007/s12034-023-03106-y
M Sheeba Gnana Selvi , RO MU Jauhar , D Sivaraj , A Suvitha , V Malarvizhi , G V Vijayaraghavan

Microbial infection is a bane to living organisms, especially humans. It is difficult to treat these infections with commercial drugs. In this context, antifungal metal oxide and carbon-based nanohybrids are an alternative due to their synergistic properties. In this work, we synthesized silver-decorated graphene oxide (Ag/GO) nanocomposite using a simple co-precipitation method. In this way, spherical silver nanoparticles are uniformly distributed over the surface of the reduced GO (rGO). The synthesized samples were characterized using various physical–chemical characterization techniques. The antifungal activity of the Ag-decorated reduced graphene oxide (Ag/rGO) composites reveals the highest zone of inhibition towards Candida albicans. It has been found that nanohybrids possess antifungal properties against C. albicans, Candida krusei and Candida tropicalis. This depends on their concentration and time of use. In-vitro antifungal activity of Ag/rGO nanocomposite reveals a higher zone of inhibition against C. albicans. These nanocomposites are useful as nanofillers in biopolymer nanocomposites for antifungal materials and potential cancer therapeutic agents.



中文翻译:

用于医疗应用的 Ag 修饰的 GO 和 rGO 纳米复合材料的增强抗真菌特性

微生物感染是生物体的祸根,尤其是人类。用商业药物很难治疗这些感染。在这种情况下,抗真菌金属氧化物和碳基纳米混合物因其协同特性而成为替代方案。在这项工作中,我们使用简单的共沉淀方法合成了银装饰的氧化石墨烯(Ag/GO)纳米复合材料。这样,球形银纳米颗粒均匀分布在还原GO(rGO)的表面。使用各种物理化学表征技术对合成的样品进行表征。银修饰的还原氧化石墨烯 (Ag/rGO) 复合材料的抗真菌活性显示出对白色念珠菌的最高抑制区域。已发现纳米杂化物具有针对念珠菌的抗真菌特性。白色念珠菌克柔念珠菌热带念珠菌。这取决于它们的浓度和使用时间。Ag/rGO 纳米复合材料的体外抗真菌活性显示出对念珠菌具有更高的抑制区域。白色念珠菌。这些纳米复合材料可用作生物聚合物纳米复合材料中的纳米填料,用于抗真菌材料和潜在的癌症治疗剂。

更新日期:2024-01-25
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