Metastasis formation is a complex process, involving multiple crucial steps, which are controlled by different regulatory mechanisms. In this context, the contribution of cancer metabolism to the metastatic cascade is being increasingly recognized. This Review focuses on changes in lipid metabolism that contribute to metastasis formation in solid tumors. We discuss the molecular mechanisms by which lipids induce a pro-metastatic phenotype and explore the role of lipids in response to oxidative stress and as signaling molecules. Finally, we reflect on potential avenues to target lipid metabolism to improve the treatment of metastatic cancers.

中文翻译：

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脂质作为癌症进展和转移的介质

转移形成是一个复杂的过程，涉及多个关键步骤，这些步骤受不同的调控机制控制。在这种背景下，癌症代谢对转移级联反应的贡献越来越受到人们的认可。本综述重点关注导致实体瘤转移形成的脂质代谢变化。我们讨论了脂质诱导促转移表型的分子机制，并探讨了脂质在响应氧化应激和作为信号分子中的作用。最后，我们思考了靶向脂质代谢以改善转移性癌症治疗的潜在途径。