According to the increasing trend of COPD, the timely diagnosis and treatment of the disease can reduce the high costs to the health systems. Therefore, by biological calculation methods, signaling pathways and genes involved in this disease can be obtained and used to design drugs and other treatment methods. By using biological calculations, we determined that curcumin can affect this disease and its genes and signaling pathways. Our goal in this study was to find the genes by which curcumin exerts its effect and can maintain the function of corticosteroids against oxidizing agents. By finding the genes, it is possible to find precisely the pathways by which curcumin works, which can be used to design other drugs that cause these pathways and minimize their side effects. This study considers healthy samples (with/without curcumin) and oxygen-free radicals (with/without curcumin). Finally, statistical algorithms extract meaningful genes as effective biomarkers to investigate curcumin's effects and signaling pathways in COPD. The results show that the genes finally obtained as the most critical genes confirmed by the literature are effective in COPD. Finally, curcumin was input in SwissTargetPrediction to identify potential protein receptors. We used LigPlot+ software to visualize the receptor–ligand binding result provided by iGEMDOCK. The data showed that the most significant genes in each group have been confirmed in other studies to be effective in this disease, and protein–protein interaction networks can be established between them to investigate their roles.

中文翻译：

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用生物计算方法评价姜黄素对慢性阻塞性肺疾病的作用

根据慢阻肺的增加趋势，及时诊断和治疗该疾病可以降低卫生系统的高额成本。因此，通过生物学计算方法，可以获得与该疾病相关的信号通路和基因，并用于设计药物和其他治疗方法。通过生物学计算，我们确定姜黄素可以影响这种疾病及其基因和信号通路。我们在这项研究中的目标是找到姜黄素发挥作用并维持皮质类固醇对抗氧化剂功能的基因。通过寻找这些基因，可以精确地找到姜黄素发挥作用的途径，这可以用来设计引起这些途径的其他药物并最大限度地减少其副作用。这项研究考虑了健康样本（含有/不含姜黄素）和氧自由基（含有/不含姜黄素）。最后，统计算法提取有意义的基因作为有效的生物标志物，以研究姜黄素在慢性阻塞性肺病中的作用和信号通路。结果表明，最终获得的基因为文献证实的最关键基因，对COPD有效。最后，将姜黄素输入 SwissTargetPrediction 中以识别潜在的蛋白质受体。我们使用 LigPlot+ 软件可视化 iGEMDOCK 提供的受体-配体结合结果。数据显示，每组中最重要的基因已在其他研究中被证实对这种疾病有效，并且可以在它们之间建立蛋白质-蛋白质相互作用网络来研究它们的作用。