: The cinnoline nucleus is a bicyclic ring and is an isosteric precursor to quinolone or isoquinoline. Cinnoline analogs are aromatic heterocyclic compounds having diverse therapeutic activities, such as antimicrobial, analgesic, anti-inflammatory, anti-tuberculosis, antimalarial, anticonvulsant, antioxidant, anticancer, antihypertensive, anti-anxiety, and other activities. This heterocyclic nucleus is attracting a lot of attention in medicinal chemistry and is used as a structural subunit in various compounds with attractive medicinal and chemical properties. In this review, we focus on the biological activities of cinnoline analogs with various substitutions.

中文翻译：

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Cinnoline 支架的多种生物活性概述

：肉桂啉核是双环，是喹诺酮或异喹啉的等排前体。肉桂啉类似物是芳香族杂环化合物，具有多种治疗活性，如抗菌、镇痛、抗炎、抗结核、抗疟、抗惊厥、抗氧化、抗癌、抗高血压、抗焦虑等活性。这种杂环核在药物化学领域引起了广泛关注，并被用作各种具有有吸引力的药物和化学性质的化合物的结构亚基。在这篇综述中，我们重点关注具有各种取代的肉桂啉类似物的生物活性。