Abstract

The importance of vitamin D3 for maintaining the level of health in conditions of the acute respiratory and vascular infectious pathology of COVID-19 is considered. Physiological vitamin deficiency has been documented as a negative predictor of virus exposure and disease severity. A complex of clinical and experimental studies document that vitamin D3 performs the function of controlling hemovascular homeostasis—the endothelium of the vascular wall, a complex of immunological reactions, coagulation and rheological properties of blood, systemic hemodynamics, etc. The variety of effects is determined by the transcriptional role of the vitamin D3 receptor, which expresses gene targets for synthesis functional protective proteins. The possibilities of supplementation, maintaining the level of vitamin D3 and its chemical metabolites, for the preventive and therapeutic strategy of COVID-19 are considered.

中文翻译：

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“阳光”维生素D3——多面、神秘、必需

摘要

人们认为维生素 D3 对于在 COVID-19 急性呼吸道和血管感染病理条件下维持健康水平的重要性。生理性维生素缺乏已被证明是病毒暴露和疾病严重程度的负面预测因素。一系列临床和实验研究表明，维生素 D3 具有控制血管稳态的功能——血管壁内皮、免疫反应、血液凝固和流变特性、全身血流动力学等的综合作用。多种作用已确定通过维生素 D3 受体的转录作用，维生素 D3 受体表达合成功能性保护蛋白的基因靶标。考虑了补充、维持维生素 D3 及其化学代谢物水平以预防和治疗 COVID-19 策略的可能性。