Senescent cancer cells, which are characteristically present in tumors after genotoxic therapies, upregulate the immune checkpoint ligand programmed cell death 1 ligand 2 (PD-L2). We show that genetic or pharmacological ablation of PD-L2 prevents the accumulation of intratumoral senescent cells, reducing the recruitment of immunosuppressive myeloid cells and facilitating tumor clearance by T cells.

中文翻译：

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衰老癌细胞中的 PD-L2 表达限制化疗后的肿瘤清除

基因毒性治疗后肿瘤中典型存在的衰老癌细胞会上调免疫检查点配体程序性细胞死亡 1 配体 2 (PD-L2)。我们发现，PD-L2 的遗传或药物消除可以防止肿瘤内衰老细胞的积累，减少免疫抑制性骨髓细胞的募集并促进 T 细胞清除肿瘤。