Abstract

The review discusses the mechanisms of monoallelic expression, such as genomic imprinting, in which gene transcription depends on the parental origin of the allele, and random monoallelic transcription. Data on the regulation of gene activity in the imprinted regions are summarized with a particular focus on the areas controlling imprinting and factors influencing the variability of the imprintome. The prospects of studies of the monoallelic expression are discussed.

中文翻译：

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基因组印记和随机单等位基因表达

摘要

该综述讨论了单等位基因表达的机制，例如基因组印记（其中基因转录取决于等位基因的亲本起源）和随机单等位基因转录。总结了印记区域基因活性调节的数据，特别关注控制印记的区域和影响印记组变异的因素。并对单等位基因表达的研究前景进行了展望。