Abstract

Autophagy is a central process for degradation of intracellular components that do not operate correctly. Molecular mechanisms underlying this process are extremely difficult to study, since they involve a large number of participants. The main task of autophagy is redistribution of cellular resources in response to environmental changes, such as starvation. Recent studies show that autophagy regulation could be the key to achieve healthy longevity, as well as to create therapeutic agents for treatment of neurodegenerative diseases such as Parkinson’s and Alzheimer’s diseases. Thus, development of autophagy activators with established detailed mechanism of action is a really important area of research. Several commercial companies are at various stages of development of such molecules, and some of them have already begun to introduce autophagy activators to the market.

中文翻译：

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自噬的合成激活剂

摘要

自噬是降解无法正常运行的细胞内成分的核心过程。这一过程背后的分子机制非常难以研究，因为它们涉及大量参与者。自噬的主要任务是重新分配细胞资源以响应环境变化，例如饥饿。最近的研究表明，自噬调节可能是实现健康长寿的关键，也是创造治疗帕金森病和阿尔茨海默病等神经退行性疾病的治疗药物的关键。因此，开发具有已建立的详细作用机制的自噬激活剂是一个非常重要的研究领域。多家商业公司正处于此类分子的不同开发阶段，其中一些公司已经开始将自噬激活剂推向市场。