Abstract

Autophagy is the process by which cell contents, such as aggregated proteins, dysfunctional organelles, and cell structures are sequestered by autophagosome and delivered to lysosomes for degradation. As a process that allows the cell to get rid of non-functional components that tend to accumulate with age, autophagy has been associated with many human diseases. In this regard, the search for autophagy activators and the study of their mechanism of action is an important task for treatment of many diseases, as well as for increasing healthy life expectancy. Plants are rich sources of autophagy activators, containing large amounts of polyphenolic compounds in their composition, which can be autophagy activators in their original form, or can be metabolized by the intestinal microbiota to active compounds. This review is devoted to the plant-based autophagy activators with emphasis on the sources of their production, mechanism of action, and application in various diseases. The review also describes companies commercializing natural autophagy activators.

中文翻译：

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自噬的天然激活剂

摘要

自噬是细胞内容物（例如聚集的蛋白质、功能失调的细胞器和细胞结构）被自噬体隔离并输送到溶酶体进行降解的过程。作为细胞清除随年龄增长而积累的非功能性成分的过程，自噬与许多人类疾病有关。因此，寻找自噬激活剂并研究其作用机制是治疗多种疾病、提高健康预期寿命的重要任务。植物是自噬激活剂的丰富来源，其成分中含有大量的多酚类化合物，它们的原始形式可以是自噬激活剂，也可以被肠道微生物代谢为活性化合物。本综述致力于植物自噬激活剂，重点介绍其生产来源、作用机制以及在各种疾病中的应用。该评论还描述了将天然自噬激活剂商业化的公司。