: Glioblastoma (GBM) is a grade-IV astrocytoma, which is the most common and aggressive type of brain tumor, spreads rapidly and has a life-threatening catastrophic effect. GBM mostly occurs in adults with an average survival time of 15 to 18 months, and the overall mortality rate is 5%. Significant invasion and drug resistance activity cause the poor diagnosis of GBM. Naringenin (NRG) is a plant secondary metabolite byproduct of the flavanone subgroup. NRG can cross the blood-brain barrier and deliver drugs into the central nervous system when conjugated with appropriate nanocarriers and can overcome the challenges associated with gliomas through naringenin-loaded nanoformulations. Here, we discuss several nanocarriers employed as delivery systems, including polymeric nanoparticles, micelles, liposomes, solid lipid nanoparticles (SLNs), nanosuspensions, and nanoemulsions. These naringenin-loaded nanoformulations have been tested in various in vitro and in vivo models and administration routes as a potential treatment for brain disorders. The conclusion from this review is that proper nanoformulations of NRG are a possible therapeutic alternative for the treatment of neurological diseases

中文翻译：

---

用于神经退行性疾病的柚皮素纳米制剂

：胶质母细胞瘤 (GBM) 是一种 IV 级星形细胞瘤，是最常见和最具侵袭性的脑肿瘤类型，扩散迅速，具有危及生命的灾难性影响。GBM多发生于成人，平均生存时间为15～18个月，总体死亡率为5%。显着的侵袭和耐药活性导致GBM的诊断不佳。柚皮素 (NRG) 是黄烷酮亚组的植物次生代谢副产物。当与适当的纳米载体结合时，NRG 可以穿过血脑屏障并将药物输送到中枢神经系统，并且可以通过负载柚皮素的纳米制剂克服与神经胶质瘤相关的挑战。在这里，我们讨论了几种用作递送系统的纳米载体，包括聚合物纳米颗粒、胶束、脂质体、固体脂质纳米颗粒（SLN）、纳米悬浮液和纳米乳液。这些负载柚皮素的纳米制剂已在各种体外和体内模型和给药途径中进行了测试，作为脑部疾病的潜在治疗方法。这篇综述的结论是，适当的 NRG 纳米制剂是治疗神经系统疾病的一种可能的治疗替代方案