RNA modification, especially N6-methyladenosine, 5-methylcytosine, and N7-methylguanosine methylation, participates in the occurrence and progression of cancer through multiple pathways. The function and expression of these epigenetic regulators have gradually become a hot topic in cancer research. Mutation and regulation of noncoding RNA, especially lncRNA, play a major role in cancer. Generally, lncRNAs exert tumor-suppressive or oncogenic functions and its dysregulation can promote tumor occurrence and metastasis. In this review, we summarize N6-methyladenosine, 5-methylcytosine, and N7-methylguanosine modifications in lncRNAs. Furthermore, we discuss the relationship between epigenetic RNA modification and lncRNA interaction and cancer progression in various cancers. Therefore, this review gives a comprehensive understanding of the mechanisms by which RNA modification affects the progression of various cancers by regulating lncRNAs, which may shed new light on cancer research and provide new insights into cancer therapy.

RNA修饰，尤其是N6-甲基腺苷、5-甲基胞嘧啶和N7-甲基鸟苷甲基化，通过多种途径参与癌症的发生和进展。这些表观遗传调控因子的功能和表达逐渐成为癌症研究的热点。非编码RNA（尤其是lncRNA）的突变和调控在癌症中发挥着重要作用。一般来说，lncRNA发挥肿瘤抑制或致癌功能，其失调可促进肿瘤的发生和转移。在这篇综述中，我们总结了 lncRNA 中的 N6-甲基腺苷、5-甲基胞嘧啶和 N7-甲基鸟苷修饰。此外，我们还讨论了表观遗传 RNA 修饰和 lncRNA 相互作用与各种癌症进展之间的关系。因此，本综述全面了解RNA修饰通过调节lncRNA影响多种癌症进展的机制，可能为癌症研究提供新的思路，并为癌症治疗提供新的见解。