Aims: The small organic molecular compounds with biological activity containing C-C and C-N or C-O bonding were efficiently prepared without catalyst and solvent in the hydrothermal synthesis reactor. Objectives: Our goal was to explore new applications for the more environmentally friendly and efficient synthesis of bis(indolyl)methyl, xanthene, quinazolinone, and N-heterocyclic derivatives in hydrothermal synthesis reactors under solvent-free and catalyst-free conditions. Methods: A greener and more efficient method was successfully developed for the synthesis of bis(indolyl)methyl, heteroanthracene, quinazolinone, and N-heterocyclic derivatives using a hydrothermal synthesis reactor in a solvent- and catalyst-free manner. Results: In a hydrothermal synthesis reactor, bis(indoyl)methyl, xanthene, quinazolinone, and N-heterocyclic derivatives were synthesized without catalysts and solvents. Conclusion: Overall, it is proved once again that the catalyst-free and solvent-free synthesis method has universal value and is a more ideal and environmentally friendly new method, especially the hydrothermal reactor for synthesis.

中文翻译：

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无催化剂、无溶剂方法温和高效制备N-杂环有机分子

目的：在水热合成反应器中，无需催化剂和溶剂，高效制备含有CC和CN或CO键的具有生物活性的有机小分子化合物。目标：我们的目标是探索在无溶剂和无催化剂条件下在水热合成反应器中更环保、更高效地合成双(吲哚基)甲基、呫吨、喹唑啉酮和N-杂环衍生物的新应用。方法：利用水热合成反应器，以无溶剂、无催化剂的方式成功开发了一种更绿色、更高效的双(吲哚基)甲基、杂蒽、喹唑啉酮和N-杂环衍生物的合成方法。结果：在水热合成反应器中，无需催化剂和溶剂即可合成双(吲哚基)甲基、呫吨、喹唑啉酮和N-杂环衍生物。结论：总体而言，再次证明无催化剂、无溶剂合成方法具有普适价值，是一种较为理想、环境友好的新方法，尤其是水热反应器进行合成。