: Squamous cell carcinoma (SCC) is the second most common form of skin cancer and is typically found on sun-exposed skin. Risk factors include ultraviolet radiation exposure, older age, fairer complexion, smoking, and immunosuppression. SCC is a slow-growing tumor with the possibility of metastasis if not treated. The clinical presentation can range from a dry, scaly erythematous patch or plaque to a firm hyperkeratotic papule, plaque, or nodule, depending on the histological type via biopsy. The first-line therapies for SCC removal are standard excision and Mohs microscopic surgery; however, there are novel and alternative non-surgical options being considered for the treatment of SCC. This review summarizes the current guidelines for treating low-risk and high-risk SCC and discusses rare, experimental, and anecdotal non-surgical treatments for SCC in the literature.

中文翻译：

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鳞状细胞癌的非常规疗法：替代治疗之旅

：鳞状细胞癌 (SCC) 是第二常见的皮肤癌，通常出现在暴露于阳光的皮肤上。危险因素包括紫外线辐射、年龄较大、肤色白皙、吸烟和免疫抑制。鳞状细胞癌是一种生长缓慢的肿瘤，如果不治疗可能会发生转移。临床表现可以是干燥、鳞状红斑或斑块，也可以是坚硬的角化过度丘疹、斑块或结节，具体取决于活检的组织学类型。鳞状细胞癌切除的一线疗法是标准切除术和莫氏显微手术；然而，正在考虑采用新颖的替代非手术选择来治疗鳞状细胞癌。本综述总结了当前治疗低风险和高风险鳞状细胞癌的指南，并讨论了文献中罕见的、实验性的和轶事性的鳞状细胞癌非手术治疗方法。