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Asymmetric construction of sulfur(VI)–fluorine cores
Nature Chemistry ( IF 21.8 ) Pub Date : 2024-02-14 , DOI: 10.1038/s41557-024-01454-8
Patrick R. Melvin

Molecules containing a chiral S(VI) moiety have found extensive applications in drug design and organic synthesis, despite a lack of diverse asymmetric methods for their creation. Now, a ligand-mediated process has enabled the production of enantioenriched S(VI)–F motifs, providing a foundation for further stereospecific elaborations.

中文翻译:

硫(VI)-氟核的不对称结构

含有手性 S(VI) 部分的分子已在药物设计和有机合成中得到广泛应用,尽管缺乏多种不对称的制备方法。现在,配体介导的过程已经能够生产对映体富集的 S(VI)–F 基序,为进一步的立体特异性阐述奠定了基础。
更新日期:2024-02-19
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