Abstract

A pragmatic double-blind randomized controlled trial was conducted in Barcelona to assess a telephone-based smoking cessation intervention’s effectiveness for individuals with mental health disorders post-discharge. Participants were divided into an intervention group (IG) and control group (CG) with a 2:1 allocation ratio. The IG received proactive motivational assistance, while the CG received brief advice. Biochemically validated past 7-day abstinence was the main outcome measure. Of 530 screened individuals, 294 were enrolled (200 IG, 94 CG). During follow-up, participants reported 97 episodes of ≥ 7-day abstinence (IG, 51; CG, 26). Overall abstinence probability was 30–35%, with no difference between groups at 1-year follow-up. However, intervention participants were more likely to report abstinence if they quit during hospitalization or were considering quitting. The intervention effectively supported smoking abstinence in motivated individuals. Combining this with clinical and community-based interventions holds promise for aiding smoking cessation in those with mental disorders. ClinicalTrials.gov Identifier: NCT03230955.

中文翻译：

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出院后基于电话的戒烟干预对严重精神健康障碍患者的有效性：061 Quitmental 随机对照临床试验

摘要

在巴塞罗那进行了一项务实的双盲随机对照试验，以评估基于电话的戒烟干预措施对出院后患有精神健康障碍的个体的有效性。参与者按 2:1 的分配比例分为干预组 (IG) 和对照组 (CG)。IG 获得了积极的激励援助，而 CG 则获得了简短的建议。经过生化验证的过去 7 天的禁欲是主要结果指标。在 530 名筛查个体中，有 294 名被登记（200 名 IG，94 名 CG）。在随访期间，参与者报告了 97 次 ≥ 7 天的禁欲事件（IG，51；CG，​​26）。总体戒烟概率为 30-35%，1 年随访时各组之间没有差异。然而，如果干预参与者在住院期间戒烟或正在考虑戒烟，他们更有可能报告戒烟。该干预措施有效支持有积极性的个体戒烟。将此与临床和社区干预措施相结合，有望帮助精神障碍患者戒烟。ClinicalTrials.gov 标识符：NCT03230955。