Liquid–liquid phase separation (LLPS) is a crucial biological process that governs biomolecular condensation, assembly, and functionality within phase-separated aqueous environments. This phenomenon serves as a source of inspiration for the creation of artificial designs in both structured and functional biomaterials, presenting novel strategies for manipulating the structures of functional protein aggregates in a wide range of biomedical applications. This mini review summarizes my past research endeavors, offering a panoramic overview of LLPS-inspired biomaterials utilized in the design of structured materials, the development of cell mimetics, and the advancement of intelligent biomaterials.

中文翻译：

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液-液相分离启发的生物材料设计

液-液相分离（LLPS）是一个重要的生物过程，控制相分离水环境中生物分子的缩合、组装和功能。这种现象为结构化和功能性生物材料的人工设计提供了灵感来源，为在广泛的生物医学应用中操纵功能性蛋白质聚集体的结构提供了新的策略。这篇简短的评论总结了我过去的研究工作，全面概述了受 LLPS 启发的生物材料在结构材料设计、细胞模拟物的开发和智能生物材料的进步中的应用。