Abstract

Background

Obesity and liver cirrhosis represent significant health challenges, often leading to various complications.

Aims

This prospective study aimed to investigate the impact of a four-year bariatric intervention, focusing on adherence to the Mediterranean Diet, on anthropometric, hematologic, and biochemical parameters in obese patients with compensated liver cirrhosis. Additionally, the study evaluated the concurrent contribution of weight loss to these health indicators.

Methods

The study involved 62 patients with compensated liver cirrhosis (mean age 65.87 ± 6 years) and 44 healthy controls (mean age 59.11 ± 8 years), all with a BMI > 30 kg/m². Both groups underwent a weight loss intervention based on the Mediterranean diet, with a four-year follow-up. Anthropometric, biochemical and hematologic parameters were evaluated at several time points during the study and their statistical significance was assessed.

Results

Anthropometric parameters, including weight, BMI, waist and hip circumference, percentage of fat mass, and handgrip strength, exhibited significant improvements (p < 0.05), particularly within the first year of the intervention. Liver function tests and lipid profiles of the patients also showed significant enhancements (p < 0.05). Hematological and biochemical indices, such as hematocrit and ferritin, experienced discreet improvements in the patient cohort (p < 0.05).

Conclusions

This study highlights the potential of a structured bariatric intervention rooted in the Mediterranean diet to positively influence the health of obese patients with compensated liver cirrhosis. The observed improvements in anthropometric, biochemical, and hematologic parameters, particularly within the first year of the intervention, suggest the importance of dietary modifications in managing the health of this patient population.

中文翻译：

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代偿性肝硬化肥胖患者的减肥营养干预：一项为期四年的前瞻性研究

摘要

背景

肥胖和肝硬化是重大的健康挑战，通常会导致各种并发症。

目标

这项前瞻性研究旨在调查为期四年的减肥干预措施，重点关注地中海饮食的坚持，对代偿性肝硬化肥胖患者的人体测量、血液学和生化参数的影响。此外，该研究还评估了减肥对这些健康指标的同时影响。

方法

该研究涉及 62 名代偿性肝硬化患者（平均年龄 65.87 ± 6 岁）和 44 名健康对照者（平均年龄 59.11 ± 8 岁），所有患者的 BMI 均> 30 kg/m ²。两组均接受了基于地中海饮食的减肥干预措施，并进行了四年的随访。在研究期间的几个时间点评估了人体测量、生化和血液学参数，并评估了它们的统计显着性。

结果

人体测量参数，包括体重、BMI、腰围和臀围、脂肪量百分比和握力，显示出显着改善（p  < 0.05），特别是在干预的第一年。患者的肝功能测试和血脂谱也显示出显着增强（p  < 0.05）。血液学和生化指标，例如血细胞比容和铁蛋白，在患者队列中经历了谨慎的改善（p  < 0.05）。

结论

这项研究强调了植根于地中海饮食的结构化减肥干预措施对代偿性肝硬化肥胖患者健康产生积极影响的潜力。观察到的人体测量、生化和血液学参数的改善，特别是在干预的第一年内，表明饮食调整在管理该患者群体健康方面的重要性。