Abstract

Introduction

High-shear wet granulation (HSWG) is most commonly used in the pharmaceutical industry, with the advantages of being fully enclosed, having a good mixing effect, and being highly efficient. However, only a few studies are geared toward an in-depth understanding of the pre-mixing process in the high-shear wet granulator (HSWGr).

Objectives

In this paper, the effect of impeller speed and fill level on the mixing performance of particles is investigated using the discrete element method (DEM), which provides theoretical references for the energy-saving operation in HSWGr.

Methods

Relative standard deviation (RSD) was used as a mixing index to quantify mixing quality, particle temperature over a vertical distance to quantify particle motion bias, and total power consumption per unit mass to monitor the loss effect.

Results

The simulation results show that the impeller speed only affects the mixing process and does not change the mixing uniformity; the fill level has a significant effect on the particle mixing, and a higher fill level will inhibit the particle mixing; based on the uniform mixing, the fill level has little effect on the total power consumption per unit mass.

Conclusion

The results of the study show that increasing the fill level and impeller speed contributes to the energy-saving operation of HSWGr.

中文翻译：

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高剪切湿法制粒预混合混合性能与功耗关系的认识

摘要

介绍

高剪切湿法制粒（HSWG）在制药行业最常用，具有全封闭、混合效果好、效率高等优点。然而，只有少数研究旨在深入了解高剪切湿法制粒机 (HSWGr) 中的预混合过程。

目标

本文采用离散元法（DEM）研究了叶轮转速和料位对颗粒混合性能的影响，为HSWGr的节能运行提供理论参考。

方法

使用相对标准偏差 (RSD) 作为混合指数来量化混合质量，使用垂直距离上的颗粒温度来量化颗粒运动偏差，并使用每单位质量的总功耗来监测损失效果。

结果

仿真结果表明，叶轮转速仅影响混合过程，不改变混合均匀度；填充位对颗粒混合有显着影响，填充位较高会抑制颗粒混合；在混合均匀的基础上，填充量对单位质量总电耗影响不大。

结论

研究结果表明，提高填充位和叶轮转速有助于HSWGr的节能运行。