The analysis of the effect of ivermectin on phytopathogenic strains of Fusarium graminearum (F‑55644, F-55748) and Fusarium oxysporum f. sp. lycopersici (F-52897, F-55547) was carried out; as a result, its concentrations were established at which a fungistatic effect on the growth of colonies of the specified strains was observed (2 and 3 mg/mL). It was found that F. oxysporum strains were more susceptible in general to ivermectin than F. graminearum strains. Since it is known that ivermectin is able to interact with β-tubulin (causing a stabilization of microtubules), to explain the obtained results, a 3-dimensional model of the complex of this compound with Fusarium β-tubulin was developed and ivermectin-induced changes in the conformation of β-tubulin were determined, including, particularly, the stabilization and spiralization of the M‑loop of the β-tubulin molecule. This structural element of β-tubulin plays an important role in the lateral contacts between tubulin subunits of adjacent protofilaments within the microtubule. Since the M-loop stabilization reflects a very important feature of microtubule stabilizing agents' binding to the taxane site of β-tubulin, it can be supposed, that ivermectin possesses the same effect on Fusarium microtubules. The results obtained allow for considering ivermectin or its derivatives as potential compounds with fungicidal activity.

伊维菌素对禾谷镰刀菌(F-55644、F-55748) 和尖孢镰刀菌植物致病菌株的影响分析。sp。进行了番茄（F-52897、F-55547）；结果，确定了观察到对特定菌株菌落生长具有抑制真菌作用的浓度（2 和 3 mg/mL）。发现尖镰孢菌株总体上比禾谷镰刀菌菌株对伊维菌素更敏感。由于已知伊维菌素能够与 β-微管蛋白相互作用（导致微管稳定），为了解释所获得的结果，开发了该化合物与镰刀菌β-微管蛋白复合物的 3 维模型，并开发了伊维菌素诱导的复合物确定了 β-微管蛋白构象的变化，特别是 β-微管蛋白分子 M 环的稳定化和螺旋化。β-微管蛋白的这种结构元件在微管内相邻原丝的微管蛋白亚基之间的横向接触中起着重要作用。由于M环稳定反映了微管稳定剂与β-微管蛋白紫杉烷位点结合的一个非常重要的特征，因此可以推测伊维菌素对镰刀菌微管具有相同的作用。所获得的结果允许将伊维菌素或其衍生物视为具有杀真菌活性的潜在化合物。