Abstract

Among germatranes, 1-germatranol hydrate is the most well-studied compound with a broad spectrum of biological activity. It is synthesized in one step by the reaction of tris(2-hydroxyethyl)amine with germanium dioxide in an aqueous medium without the use of organic solvents. Using this approach, new potentially biologically active compounds of germanium with hydroxyalkylamines and sulfonic and amino acids containing hydroxyalkyl groups were synthesized. The products were considered as new analogues of biologically active 1-germatranol hydrate. Their formation was confirmed by the results of elemental analysis, IR and NMR spectroscopy. In silico ADME and Pass analysis were used to assess the potential bioavailability and pharmacological activity profiles for new compounds. The results of in vitro study of the antiviral activity (influenza virus A/Aichi/2/68 (H3N2)) of the synthesized compounds are presented.

中文翻译：

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超配位锗与含羟烷基配体的配合物

摘要

在吉马川烷中，1-吉马川醇水合物是研究最深入的化合物，具有广泛的生物活性。它是通过三(2-羟乙基)胺与二氧化锗在水介质中反应一步合成的，无需使用有机溶剂。利用这种方法，合成了具有潜在生物活性的新的锗与羟烷基胺以及含有羟烷基的磺酸和氨基酸的化合物。该产品被认为是具有生物活性的 1-germatranol 水合物的新类似物。元素分析、红外光谱和核磁共振光谱的结果证实了它们的形成。计算机 ADME 和 Pass 分析用于评估新化合物的潜在生物利用度和药理活性特征。介绍了合成化合物的抗病毒活性（流感病毒 A/Aichi/2/68 (H3N2)）的体外研究结果。