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High Inhibition Activity of CQDs-Macaranga tanarius Organic Framework Nanomaterial-Based Antibacterials
Indian Journal of Microbiology ( IF 3 ) Pub Date : 2024-03-09 , DOI: 10.1007/s12088-024-01230-9
Saparuddin Saparuddin , Djunarlin Tojang , Alimuddin Alimuddin , Zul Arham

Antibacterial agent based on modification of Macaranga tanarius (M. tanarius) extract into CQDs@M. tanarius has been successfully synthesized and applied against Escherichia coli and Staphylococcus aureus. Macaranga tanarius plants were obtained from Buton Island, Southeast Sulawesi-Indonesia, and used as precursors for Carbon Quantum Dots (CQDs). In the synthesis, the dried leaves of M. tanarius were macerated, and then the filtrate was modified hydrothermally in a Teflon-lined stainless steel autoclave. The modification results produce nano-sized CQDs@M. tanarius particles. The PSA test confirmed this, which described the CQDs@M. tanarius particle size as 57.0 nm. The results of UV–Vis spectroscopy tests illustrate that the CQDs@M. tanarius molecules experience π → π* and n → π* electronic transitions at a wavelength of 367 nm. Meanwhile, in the FTIR spectroscopy test, stretching vibrations from the functional groups –OH, C–H, C=O, C–O, and the benzene ring were observed at wave numbers 3415.93 cm−1, 2976.16 cm−1, 1641.42 cm−1, 1274.95 cm−1, and 692.44 cm−1, respectively. Based on the antibacterial activity test, it is known that CQDs@M. tanarius has high inhibitory activity against E. coli and S. aureus. The resulting inhibition diameters are 15.82 mm and 11.24 mm, respectively. This high inhibitory diameter further illustrates the potential of CQDs@M. tanarius for its further application as an antibacterial material in the future.



中文翻译:

CQDs-血桐有机框架纳米材料抗菌剂的高抑制活性

成功合成了血桐提取物CQDs @ M. tanarius抗菌剂,并应用于抗大肠杆菌金黄色葡萄球菌血桐植物取自印度尼西亚苏拉威西东南部的布顿岛,用作碳量子点 (CQD) 的前体。在合成过程中,将干燥的桐叶浸渍,然后将滤液在聚四氟乙烯内衬的不锈钢高压釜中进行水热改性。修饰结果产生纳米尺寸的CQDs@ M. tanarius颗粒。PSA 测试证实了这一点,其描述的 CQDs@ M. tanarius粒径为 57.0 nm。紫外-可见光谱测试结果表明,CQDs@ M. tanarius分子在 367 nm 波长处经历 π → π* 和 n → π* 电子跃迁。同时,在FTIR光谱测试中,在波数3415.93 cm -1、2976.16 cm -1、1641.42 cm处观察到来自官能团-OH、C-H、C=O、C-O和苯环的伸缩振动。分别为-1、1274.95 cm -1和692.44 cm -1。根据抗菌活性测试可知,CQDs@ M. tanarius对大肠杆菌金黄色葡萄球菌具有较高的抑制活性。所得抑制直径分别为 15.82 毫米和 11.24 毫米。这种高抑制直径进一步说明了 CQDs@ M. tanarius在未来作为抗菌材料进一步应用的潜力。

更新日期:2024-03-11
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