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The Emerging Role of Polyethylene Glycol-Water (PEG-H2O) as the Benign Mixed Solvent System in Organic Synthesis
Current Organic Synthesis ( IF 1.8 ) Pub Date : 2024-03-15 , DOI: 10.2174/0115701794284081240206043435
Chitteti Divyavani 1 , Pannala Padmaja 2 , Pedavenkatagari Narayana Reddy 3
Affiliation  

: Polyethylene glycol (PEG) has become a popular solvent and green catalyst for a variety of chemical reactions. It is a stable and biodegradable polymeric catalyst used in organic synthesis because it may be recycled numerous times without significantly losing its catalytic activity. Recently, the use of PEG-H2O mixed solvent systems in organic synthesis has gained popularity. This article presents an overview of PEG-H2O solvent system-mediated organic reactions, with a main focus on the importance of the solvent system. The study also focuses on recent developments in the PEG-H2O solvent system-mediated synthesis of a number of heterocy-clic compounds. Important characteristics of these PEG-H2O solvent systems include high atom economies, gentle reaction conditions, faster reaction rates, readily isolated side products and high yields. Results from various reactions showed that the choice of proper ratio of PEG: H2O solvent system plays a key role in product yields.

中文翻译:

聚乙二醇-水(PEG-H2O)作为良性混合溶剂体系在有机合成中的新兴作用

:聚乙二醇 (PEG) 已成为多种化学反应的流行溶剂和绿色催化剂。它是一种用于有机合成的稳定且可生物降解的聚合物催化剂,因为它可以多次回收而不会显着丧失其催化活性。近年来,PEG-H2O混合溶剂体系在有机合成中的应用越来越受欢迎。本文概述了 PEG-H2O 溶剂系统介导的有机反应,主要关注溶剂系统的重要性。该研究还重点关注 PEG-H2O 溶剂系统介导的多种杂环化合物合成的最新进展。这些 PEG-H2O 溶剂系统的重要特征包括高原子经济性、温和的反应条件、更快的反应速率、易于分离的副产物和高产率。各种反应的结果表明,选择适当的 PEG: H2O 溶剂系统比例对产物收率起着关键作用。
更新日期:2024-03-15
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