Abstract

Advanced glycation end products (AGE) in complex with their receptors (RAGE) cause a chronic inflammatory state in the body, which is the major mechanism in cancer development. This study aimed to conduct a systematic review and meta-analysis on the observational studies investigating the association between AGEs / sRAGE and cancer incidence. The PubMed, Scopus, and Web of Science databases were comprehensively searched to identify papers focused on the associations of sRAGE and AGEs with cancer incidence up to May 2023. Eight studies with a total of 7690 participants were included in the analysis to evaluate the association between circulating sRAGE and cancer incidence. The results indicated that circulating sRAGE (per 100 ng/L) had a significant inverse association with cancer incidence (RR 0.977; 95% CI 0.956, 0.999; p = 0.036; I ² = 73.3%). The association between AGEs and cancer incidence was evaluated in 8 studies with a total of 3718 individuals. Serum concentrations of AGEs (per 100 µg/L) were not associated with the risk of cancer incidence (RR 0.988; 95% CI 0.974, 1.002; p = 0.08; I2 = 78.8%). Our findings revealed that a higher circulating sRAGE may have a protective effect against cancer incidence.

Graphical Abstract

中文翻译：

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循环晚期糖基化终末产物及其可溶性受体与癌症风险的关联：观察性研究的系统回顾和荟萃分析

摘要

晚期糖基化终末产物 (AGE) 与其受体 (RAGE) 复合导致体内慢性炎症状态，这是癌症发展的主要机制。本研究旨在对 AGEs / sRAGE 与癌症发病率之间关系的观察性研究进行系统回顾和荟萃分析。截至 2023 年 5 月，对 PubMed、Scopus 和 Web of Science 数据库进行了全面检索，以找出重点关注 sRAGE 和 AGE 与癌症发病率之间关系的论文。分析中纳入了 8 项研究，共计 7690 名参与者，以评估 sRAGE 和 AGE 与癌症发病率之间的关联。循环 sRAGE 和癌症发病率。结果表明，循环sRAGE（每100 ng/L）与癌症发病率呈显着负相关（RR 0.977；95% CI 0.956, 0.999；p = 0.036；I ²  = 73.3%）。8 项研究总共涉及 3718 名受试者，评估了 AGE 与癌症发病率之间的关联。AGEs 血清浓度（每 100 µg/L）与癌症发病风险无关（RR 0.988；95% CI 0.974, 1.002；p = 0.08；I2  = 78.8%）。我们的研究结果表明，较高的循环 sRAGE 可能对癌症发病率具有保护作用。

图形概要