The unearthing of various forms of broad and narrow-spectrum antibiotics have helped mankind combat various forms of microbic infections ranging from protozoal to bacterial. The applicability of antibiotics has been decisive in a wide range of frontline therapeutic dealings. An extensive use of antibiotics and certain genetic modifications in microbes has paved the way for a new issue to be answered by the scientific community, an antibiotic resistance. An unparallel infections triggered by multidrug-resistant organisms (MDRO) account to be a major cause of mortality and morbidity, today this situation demands the development of alternative strategies of cure and medicine by the scientific community. Study shows the amplification of the effect of antibiotics may be a possible route to address antibiotic resistivity. The assortment of various surface properties of nanoparticles (NPs) coupled with their ability to efficiently bind with bacterial surfaces leading to the rupture and lysis of cell deliberates potential strategies to manage infections caused by MDROs.The present study scrutinizes the amplification of the antibacterial activity of ciprofloxacin (CIP) against the bacterial strains of Staphylococcus aureus, Escherichia coli, Pseudomonas and Streptococcus mutans on coupling with synthesized copper, silver and zinc oxide NPs (ZnO NPs) by disc diffusion technique. The current study describes the efficacious synthesis and characterization of ZnONP, copper Nps (CuNPs) and silver NPs (AgNPs) followed by the induced amplification of the antibacterial activity of CIP by coupling it with synthesized metal/metal oxide (M/MO NP). The synthesized M/MO NPs were characterized using XRD and FE-SEM studies and TEM. The results indicated that among the ZnONP, AgNP, the Cu NPs potentiate the bactericidal efficacy of CIP antibiotics.

各种形式的广谱和窄谱抗生素的发现帮助人类对抗从原虫到细菌的各种形式的微生物感染。抗生素的适用性在广泛的一线治疗中具有决定性作用。抗生素的广泛使用和微生物的某些基因改造为科学界解决一个新问题——抗生素耐药性——铺平了道路。由多重耐药菌（MDRO）引发的前所未有的感染是死亡和发病的主要原因，今天这种情况要求科学界制定替代治疗和医学策略。研究表明，放大抗生素的作用可能是解决抗生素耐药性的一个可能途径。纳米颗粒 (NP) 的各种表面特性及其与细菌表面有效结合导致细胞破裂和裂解的能力，考虑了管理 MDRO 引起的感染的潜在策略。本研究仔细研究了纳米颗粒抗菌活性的放大环丙沙星(CIP)通过圆盘扩散技术与合成的铜、银和氧化锌纳米粒子(ZnO NPs) 偶联，对抗金黄色葡萄球菌、大肠杆菌、假单胞菌和变形链球菌的细菌菌株。目前的研究描述了 ZnONP、铜纳米粒子 (CuNPs) 和银纳米粒子 (AgNPs) 的有效合成和表征，然后通过将其与合成的金属/金属氧化物 (M/MO NP) 偶联来诱导放大 CIP 的抗菌活性。使用 XRD、FE-SEM 研究和 TEM 对合成的 M/MO NP 进行了表征。结果表明，ZnONP、AgNP、Cu NPs 增强了 CIP 抗生素的杀菌效果。