Behavioral addictions (BA) and substance use disorders (SUDs) share core features, including impaired control and craving, leading to significant personal and societal impacts. Previous research has identified the pre-supplementary motor area (pre-SMA) as a critical node in GD-related neurocircuitry, making it a potential target for interventions also in SUDs. Theta-burst stimulation (TBS) offers a non-invasive method to modulate pre-SMA activity. This study included 58 participants diagnosed with GD or SUDs. They underwent bilateral pre-SMA continuous TBS (cTBS) sessions targeting craving, impulsivity, and addiction severity. Standardized scales and questionnaires were employed to assess the outcomes. cTBS parameters included 20 daily sessions with 80% resting motor threshold (RMT). Both GD and SUD groups exhibited significant reductions in addiction severity and craving following cTBS. Impulsivity decreased significantly in SUD but not in GD. The study’s findings underscore the potential of pre-SMA TBS as an adjunctive treatment for GD and SUDs. The observed improvements in addiction severity and craving emphasize the shared neuronal mechanisms underlying these disorders. However, the nuanced differences, especially in impulsivity, indicate the need for further research to tailor interventions precisely.

行为成瘾（BA）和物质使用障碍（SUD）具有共同的核心特征，包括控制力和渴望受损，从而导致重大的个人和社会影响。先前的研究已确定前补充运动区 (pre-SMA) 是 GD 相关神经回路的关键节​​点，使其成为 SUD 干预的潜在目标。Theta 突发刺激 (TBS) 提供了一种调节前 SMA 活动的非侵入性方法。这项研究包括 58 名被诊断患有 GD 或 SUD 的参与者。他们接受了针对渴望、冲动和成瘾严重程度的双边 SMA 前连续 TBS (cTBS) 治疗。采用标准化量表和问卷来评估结果。cTBS 参数包括 20 次每日训练，静息运动阈值 (RMT) 为 80%。GD 组和 SUD 组在 cTBS 后均表现出成瘾严重程度和渴望显着降低。SUD 中的冲动性显着下降，但 GD 中则没有。该研究的结果强调了 SMA 前 TBS 作为 GD 和 SUD 辅助治疗的潜力。观察到的成瘾严重程度和渴望的改善强调了这些疾病背后的共同神经元机制。然而，细微的差异，尤其是冲动方面的差异，表明需要进一步研究以精确调整干预措施。