Abstract

Direct transition-metal free bond activation and bond formation reaction are central to the development of a sustainable and effective strategy for the synthesis of organic molecules. Facile, aerobic, regiospecific, base-mediated transition metal-free, and direct arylation reactions with inexpensive nitroarenes are need to explore. The use of strong base, promotes the vicarious nucleophilic substitution in nitroarenes. Moreover, functional group modification of synthesized nitroarenes compounds can open myriad applications in pharmaceutical and material industries. In this review, we summarize the recent progress achieved in the transition metal-free, base-mediated methodology has been employed for mono arylation, di-arylation, acylation, and aroylation reactions and we cover the research literature from 2013 to 2022. This review article presents the advantages, limitations, mechanistic rationalization, and future perspectives associated with synthetic methodologies.

中文翻译：

---

碱介导的硝基芳烃的无过渡金属区域特异性取代：硝基芳烃中氢的替代亲核取代

摘要

直接过渡金属自由键活化和成键反应是开发可持续且有效的有机分子合成策略的核心。需要探索与廉价硝基芳烃进行简便、有氧、区域特异性、碱介导的无过渡金属和直接芳基化反应。强碱的使用促进硝基芳烃中的替代亲核取代。此外，合成硝基芳烃化合物的官能团修饰可以在制药和材料工业中开辟无数应用。在这篇综述中，我们总结了无过渡金属、碱介导的方法用于单芳基化、二芳基化、酰化和芳酰化反应的最新进展，并涵盖了 2013 年至 2022 年的研究文献。这篇综述文章介绍了与合成方法相关的优点、局限性、机械合理化和未来前景。