Abstract

Over the past decades, an unimaginably large number of attempts have been made to restore the structure of mammalian organs after injury by introducing stem cells into them. However, this procedure does not lead to full recovery. At the same time, it is known that complete regeneration (restitution without fibrosis) is possible in organs with proliferating parenchymal cells. An analysis of such models allows to conclude that the most important condition for the repair of histological structures of an organ (in the presence of stem cells) is preservation of the collagen frame structures in it, which serve as “guide rails” for proliferating and differentiating cells. An alternative condition for complete reconstruction of organ structures is the presence of a free “morphogenetic space” containing a gel-like matrix of the embryonic-type connective tissue, which exists during embryonal development of organs in mammals or during complete regeneration in amphibians. Approaches aimed at preserving frame structures or creating a “morphogenetic space” could radically improve the results of organ regeneration using both local and exogenous stem cells.

中文翻译：

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器官框架元件或游离细胞间凝胶状基质是再生过程中构建器官结构的必要条件

摘要

在过去的几十年里，人们进行了大量的尝试，通过将干细胞引入哺乳动物器官来恢复损伤后的结构。然而，此过程不会导致完全恢复。同时，众所周知，在实质细胞增殖的器官中完全再生（无纤维化的恢复）是可能的。对此类模型的分析可以得出结论，修复器官组织学结构（在干细胞存在的情况下）的最重要条件是保存其中的胶原蛋白框架结构，该结构充当增殖和增殖的“导轨”。分化细胞。器官结构完全重建的另一个条件是存在一个自由的“形态发生空间”，其中包含胚胎型结缔组织的凝胶状基质，该基质存在于哺乳动物器官的胚胎发育过程中或两栖动物的完全再生过程中。旨在保留框架结构或创建“形态发生空间”的方法可以从根本上改善使用本地和外源干细胞的器官再生的结果。