Morphology and function in a fetal heart with severe tricuspid regurgitation remains challenging. The aim of this study was to assess cardiac morphology and function in fetuses with severe tricuspid regurgitation by fetal heart quantification (HQ) and to assess the practical value of fetal HQ. Clinical information was analyzed for 63 pregnant women who underwent fetal cardiac ultrasonography. The women were divided into those who had a fetus with severe tricuspid regurgitation (n = 20) and those with a normal fetus (n = 40). The global sphericity index (GSI), fractional area change (FAC), and global longitudinal strain (GLS) of both ventricles and the sphericity index (SI) and fractional shortening (FS) of 24 segments were quantified by fetal HQ using speckle tracking imaging. Fetuses with severe tricuspid regurgitation had a significantly lower GSI (1.14 ± 0.10 vs. 1.26 ± 0.08, p < 0.001) and a higher GSI Z-score (-0.98 ± 1.01 vs. 0.25 ± 0.87, p < 0.001) as well as a significantly lower right ventricular FAC (36.50 ± 7.34% vs. 45.19 ± 3.39%, p < 0.001), FAC Z-score (-1.02 ± 1.41 vs. 0.49 ± 0.74, p < 0.001), and GLS (-21.01 ± 5.66% vs. 45.19 ± 3.49%, p < 0.001). The SI and SI Z-score were significantly lower in segments 1–18 of the right ventricle in fetuses with severe tricuspid regurgitation (p < 0.05); furthermore, FS of segments 1–12 and 19–24 and the FS Z-score of segments 18–24 were significantly lower in fetuses with severe tricuspid regurgitation (p < 0.05). Fetal HQ is useful for evaluation of cardiac morphology and function in fetuses with severe tricuspid regurgitation and can provide important reference information for both clinical diagnosis and treatment.

严重三尖瓣反流的胎儿心脏的形态和功能仍然具有挑战性。本研究的目的是通过胎心定量（HQ）评估严重三尖瓣反流胎儿的心脏形态和功能，并评估胎儿HQ的实用价值。对 63 名接受胎儿心脏超声检查的孕妇的临床信息进行了分析。这些妇女被分为胎儿严重三尖瓣反流的妇女（n = 20）和胎儿正常的妇女（n = 40）。胎儿 HQ 使用散斑跟踪成像对两个心室的整体球形指数 (GSI)、面积变化分数 (FAC) 和整体纵向应变 (GLS) 以及 24 个节段的球形指数 (SI) 和缩短分数 (FS) 进行量化。患有严重三尖瓣反流的胎儿的 GSI 显着较低（1.14 ± 0.10 对比 1.26 ± 0.08，p  < 0.001），GSI Z 得分较高（-0.98 ± 1.01 对比 0.25 ± 0.87，p  < 0.001），并且显着降低右心室 FAC（36.50 ± 7.34% 对比 45.19 ± 3.39%，p  < 0.001）、FAC Z 评分（-1.02 ± 1.41 对比 0.49 ± 0.74，p  < 0.001）和 GLS（-21.01 ± 5.66%）与 45.19 ± 3.49%，p  < 0.001）。严重三尖瓣反流胎儿右心室第 1-18 段的 SI 和 SI Z 评分显着较低（p  < 0.05）；此外，严重三尖瓣反流胎儿的 1-12 节段和 19-24 节段的 FS 以及 18-24 节段的 FS Z 评分显着较低（p  < 0.05）。胎儿HQ可用于评估严重三尖瓣关闭不全胎儿的心脏形态和功能，为临床诊断和治疗提供重要参考信息。