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Synthesis of two nitrogen-containing polyaromatic compounds through gold catalysis/DBU-promoted cyclizations
Chemical Communications ( IF 4.9 ) Pub Date : 2024-03-25 , DOI: 10.1039/d4cc00113c
Vikas Ashokrao Sadaphal, Tien-Lin Wu, Rai-Shung Liu

This work reports an efficient synthesis of novel benzo[7,8]indolizino[2,3,4,5-ija]quinazoline derivatives between 2-(2-ethynylaryl)acetonitriles 1 and anthranils 2. The synthetic approach involves the initial formation of 7-formylindole intermediates that can be implemented by DBU to activate a novel indole–nitrile–aldehyde cyclization.

中文翻译:

金催化/DBU促进环化合成两种含氮多芳香族化合物

这项工作报告了在 2-(2-乙炔基芳基)乙腈 1 和邻氨基苯酚 2 之间有效合成新型苯并[7,8]吲嗪基[2,3,4,5- ija ]喹唑啉衍生物。合成方法涉及初始形成7-甲酰基吲哚中间体,可以通过 DBU 来激活新型吲哚-腈-醛环化。
更新日期:2024-03-28
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