Epilepsy is a neural network disorder caused by uncontrolled neuronal hyperexcitability induced by an imbalance between excitatory and inhibitory networks. Abnormal synaptogenesis plays a vital role in the formation of overexcited networks. Recent evidence has confirmed that thrombospondin-1 (TSP-1), mainly secreted by astrocytes, is a critical cytokine that regulates synaptogenesis during epileptogenesis. Furthermore, numerous studies have reported that TSP-1 is also involved in other processes, such as angiogenesis, neuroinflammation, and regulation of Ca²⁺ homeostasis, which are closely associated with the occurrence and development of epilepsy. In this review, we summarize the potential contributions of TSP-1 to epilepsy development.

癫痫是一种神经网络疾病，是由于兴奋性网络和抑制性网络之间的不平衡导致神经元过度兴奋而不受控制而引起的。异常的突触发生在过度兴奋网络的形成中起着至关重要的作用。最近的证据证实，血小板反应蛋白-1（TSP-1）主要由星形胶质细胞分泌，是在癫痫发生过程中调节突触发生的关键细胞因子。此外，大量研究报道TSP-1还参与血管生成、神经炎症、Ca ²⁺稳态调节等其他过程，这些过程与癫痫的发生和发展密切相关。在这篇综述中，我们总结了 TSP-1 对癫痫发展的潜在贡献。