Progeria, or premature ageing, is a devastating condition caused by defects in the nuclear envelope and is associated with systemic inflammation. A study now shows in animal models that inhibiting necroptosis, and particularly activity of the RIPK1 kinase, reduces inflammation and results in a meaningful extension in lifespan1.

中文翻译：

---

RIPK1 和坏死性凋亡在过早衰老中的作用

早衰症或过早衰老是一种由核膜缺陷引起的破坏性病症，并与全身炎症有关。现在的一项研究表明，在动物模型中抑制坏死性凋亡，特别是抑制 RIPK1 激酶的活性，可以减少炎症并显着延长寿命1。