Herein, a palladium-catalyzed regioselective alkynylation, esterification, and amination of allylic gem-difluorides via C–F bond activation/transmetallation/β-C elimination or nucleophilic attack has been achieved. This innovative protocol showcases an extensive substrate range and operates efficiently under mild reaction conditions, resulting in high product yields and Z-selectivity. Particularly noteworthy is its exceptional tolerance towards a wide array of functional groups. This developed methodology provides effective and convenient routes to access a diverse array of essential fluorinated enynes, esters and amines.

中文翻译：

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钯催化烯丙基偕二氟化物的炔基化

在此，通过C-F键活化/金属转移/β-C消除或亲核攻击，实现了钯催化的烯丙基偕二氟化物的区域选择性炔基化、酯化和胺化。这种创新方案展示了广泛的底物范围，并在温和的反应条件下高效运行，从而实现高产物产率和Z选择性。特别值得注意的是它对多种官能团的卓越耐受性。这种开发的方法提供了有效且便捷的途径来获取各种必需的氟化烯炔、酯和胺。