The widespread implementation of solid-state nanopores faces challenges such as lower resolution and increased electrical noise when compared to biological nanopores. Incorporating specific nucleic acid reactions can enhance resolution. In this study, we’ve developed a nucleic acid amplifier to enhance the sensitivity of solid-state nanopores, utilizing a G-rich sequence and hybridization chain reaction. This amplifier improves target concentration and volume amplification, showing promise in nanopore sensitivity tests.

中文翻译：

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基于双环杂交链式反应和 G-四链体的纳米孔敏化

与生物纳米孔相比，固态纳米孔的广泛应用面临着分辨率较低和电噪声增加等挑战。结合特定的核酸反应可以提高分辨率。在这项研究中，我们开发了一种核酸放大器，利用富含 G 的序列和杂交链式反应来增强固态纳米孔的灵敏度。该放大器提高了目标浓度和体积放大，在纳米孔灵敏度测试中显示出前景。