The considerable changes in lifestyle patterns primarily affect the human gut microbiota and result in obesity, diabetes, dyslipidemia, renal complications, etc. though there are few traditional safeguards such as herbal brews to maintain the ecological stability under intestinal dysbiosis. The present article is designed to collect all the scientific facts in a place to decipher the role of the Indian traditional herbal brews used to balance gut health for centuries. Computerized databases, commercial search engines, research papers, articles, and books were used to search by using different keywords to select the most appropriate published articles from 2000 onward to September 2023. A total of 1907 articles were scrutinized, 46 articles were finally selected from the 254 screened, and targeted information was compiled. Interaction of herbal brews to the gut microflora and resulting metabolites act as prebiotics due to antimicrobial, anti-inflammatory, and antioxidant properties, and modulate the pH of the gut. The effect of brews on gut microbiota has a drastic impact on various gut-related diseases and has gained popularity as an alternative to antibiotics against bacteria, fungi, viruses, parasites, and boosting the immune system and strengthening the intestinal barrier. Berberine, kaempferol, piperine, and quercetin have been found in more than one brew discussed in the present article. Practically, these brews balance the gut microbiota, prevent chronic and degenerative diseases, and reduce organ inflammation, though, there is a knowledge gap on the molecular mechanism to explain their efficacy. Indian traditional herbal brews used to reboot and heal the gut microbiota since centuries-old practice with successful history without toxicity. The systematic consumption of these brews under specific dietary prescriptions has a hope of arrays for a healthy human gut microbiome in the present hasty lifestyle with overall health and well-being.

Graphical Abstract

中文翻译：

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印度传统草药酿造与肠道菌群平衡的相关性

生活方式的巨大变化主要影响人类肠道菌群，导致肥胖、糖尿病、血脂异常、肾脏并发症等，尽管传统的保护措施（如草药酿造）很少能在肠道菌群失调的情况下维持生态稳定。本文旨在收集所有科学事实，以解读几个世纪以来用于平衡肠道健康的印度传统草药酿造的作用。利用计算机数据库、商业搜索引擎、研究论文、文章和书籍，使用不同的关键词进行搜索，选择2000年至2023年9月最合适的发表文章。共审查了1907篇文章，最终筛选出46篇文章。筛选了254个，并整理了有针对性的信息。草药与肠道菌群的相互作用以及由此产生的代谢物由于具有抗菌、抗炎和抗氧化特性而充当益生元，并调节肠道的 pH 值。啤酒对肠道微生物群的影响对各种肠道相关疾病具有巨大影响，并且作为抗生素的替代品来对抗细菌、真菌、病毒、寄生虫，并增强免疫系统和增强肠道屏障，因此受到欢迎。在本文讨论的不止一种啤酒中都发现了小檗碱、山奈酚、胡椒碱和槲皮素。实际上，这些啤酒可以平衡肠道微生物群，预防慢性和退行性疾病，并减少器官炎症，尽管在解释其功效的分子机制上存在知识空白。印度传统草药酿造用于重启和治愈肠道微生物群，已有数百年历史，具有成功且无毒的历史。在特定的饮食处方下系统地饮用这些啤酒，有望在目前匆忙的生活方式中保持健康的人类肠道微生物群，并实现整体健康和福祉。

图形概要