A series of 3-chloro-1-aryl-4-dihydro-2H-pyrrolo[2,3-b]quinoxalin-2-ones and 3-chloro-1-aryl-6,7-dimethyl-1,4-dihydro-2H-pyrrolo[2,3-b]quinoxalin-2-ones was prepared by the condensation of o-phenylenediamine or 4,5-dimethyl-1,2-aminobenzene with N-aryl-3,4-dichloro-maleimides. All the prepared quinoxalines were tested for their antitumor activity against three human cancer cell lines (prostate cells PC3, colorectal cells Caco-2, and cervical cells HeLa), and a mammalian cell line (Vero cells). The compounds were also tested for their antibacterial properties against three different bacterial cells Escherichia coli, Bacillus spizizenii, and Pseudomonas aeruginosa. The compounds 3c, 3d, 3g, 3h, 3i and 4a, 4b, 4h showed anti-proliferative activity against the tested cell lines. Regarding their antibacterial activity, compounds 3a, 3g, 4a, and 4h showed inhibitory activity against E. coli, and B. spizizenii only.

中文翻译：

---

一类新的吡咯并[2,3-b]喹喔啉：合成、抗癌和抗菌活性

一系列3-氯-1-芳基-4-二氢-2H-吡咯[2,3-乙]喹喔啉-2-酮和3-氯-1-芳基-6,7-二甲基-1,4-二氢-2H-吡咯[2,3-乙]喹喔啉-2-酮通过缩合制备哦-苯二胺或 4,5-二甲基-1,2-氨基苯氮-芳基-3,4-二氯-马来酰亚胺。测试了所有制备的喹喔啉对三种人类癌细胞系（前列腺细胞 PC3、结直肠细胞 Caco-2 和宫颈细胞 HeLa）和一种哺乳动物细胞系（Vero 细胞）的抗肿瘤活性。还测试了这些化合物对三种不同细菌细胞的抗菌特性大肠杆菌,斯皮泽泽芽孢杆菌，和铜绿假单胞菌。化合物3c、3d、3g、3h、3i和4a、4b、4h对测试的细胞系显示出抗增殖活性。关于其抗菌活性，化合物 3a、3g、4a 和 4h 显示出对细菌的抑制活性。大肠杆菌， 和斯皮泽泽伯母仅有的。